[State of the Art: Statin Therapy]. / State of the Art: Therapie mit Statinen.
Dtsch Med Wochenschr
; 147(1-02): 62-68, 2022 Jan.
Article
em De
| MEDLINE
| ID: mdl-34872149
ABSTRACT
This review summarizes the pharmacology and clinical use of HMG-CoA reductase inhibitors, statins. LDL-Cholesterol lowering with statins reduces atherosclerotic cardiovascular risk by approx. one quater per year of treatment. The efficacy and safety of statins are demonstrated by randomized trials irrespective of the patient's age. The synthetic statins, rosuvastatin and atorvastatin, are superior with regard to LDL-C lowering, half-life and drug-interactions compared to the older statins such as simvastatin. Modern lipid lowering therapy uses individualized statin-based combination therapies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Aterosclerose
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
De
Ano de publicação:
2022
Tipo de documento:
Article