Diabetic foot ulcers: Retrospective comparative analysis from Sicily between two eras.
PLoS One
; 16(12): e0259405, 2021.
Article
em En
| MEDLINE
| ID: mdl-34874944
ABSTRACT
AIM:
The aim of this study was to analyze changes in the incidence, management and mortality of DFU in Sicilian Type 2 diabetic patients hospitalized between two eras, i.e. 2008-2013 and 2014-2019.METHODS:
We compared the two eras, era1 2008-13, era2 2014-19. In era 1, n = 149, and in era 2, n = 181 patients were retrospectively enrolled.RESULTS:
In the population hospitalized for DFU in 2008-2013, 59.1% of males and 40.9% of females died, whilst in 2014-2019 65.9% of males and 34.1% of females died. Moderate chronic kidney disease (CKD) was significantly higher in patients that had died than in ones that were alive (33% vs. 43%, p < 0.001), just as CKD was severe (14.5% vs. 4%, p < 0.001). Considering all together the risk factors associated with mortality, at Cox regression multivariate analysis only moderate-severe CKD (OR 1.61, 95% CI 1.07-2.42, p 0.021), age of onset greater than 69 years (OR 2.01, 95% CI 1.37-2.95, p <0.001) and eGFR less than 92 ml/min (OR 2.84, 95% CI 1.51-5.34, p 0.001) were independently associated with risk of death.CONCLUSIONS:
Patients with DFU have high mortality and reduced life expectancy. Age at onset of diabetic foot ulcer, eGFR values and CKD are the principal risk factors for mortality.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pé Diabético
/
Diabetes Mellitus Tipo 2
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Insuficiência Renal Crônica
Tipo de estudo:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article