Smartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots.
Mater Today Bio
; 12: 100168, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-34877521
ABSTRACT
A simple, cost-effective system was developed for dopamine (DA) detection using green synthesized 1-6 ânm honey-based carbon quantum dots (H-CQDs) exhibiting bluish green fluorescence. The H-CQDs exhibited emission at 445 ânm, with a quantum yield of â¼44%. The H-CQDs were used as a probe for electron transfer based DA detection and changes in H-CQD color in the presence of DA. The H-CQDs were formed with polar functional groups and were highly soluble in aqueous media. In the fluorometric mode, the proposed system demonstrated high specificity toward DA and effective limit of detection (LOD) values of 6, 8.5, and 8 ânM in deionized (DI) water, male geriatric plasma, and female geriatric plasma, respectively, in the linear range 100 ânM-1000 µM. In the colorimetric mode, the color changed within 5 âmin, and the LOD was 163 âµM. A colorimetric sensor array system was used to precisely detect DA with a smartphone-integrated platform using an in house built imaging application and an analyzer app. Additionally, no additives were required, and the H-CQDs were not functionalized. More importantly, the H-CQDs were morphologically and analytically characterized before and after DA detection. Because the sensor array-based system allows high specificity DA detection in both DI water and geriatric plasma, it will play an important role in biomedical applications.
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Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article