Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities.
Molecules
; 26(23)2021 Nov 27.
Article
em En
| MEDLINE
| ID: mdl-34885772
ABSTRACT
Three novel monoterpenoid indole alkaloids gardflorine A (1), gardflorine B (2), and gardflorine C (3) were isolated from the leaves of Gardneria multiflora. Their structures, including absolute configurations, were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and circular dichroism experiments. All the compounds were evaluated for their vasorelaxant and acetylcholinesterase (AChE) inhibitory activities. Compound 1 exhibited potent vasorelaxant activity, with an EC50 value of 8.7 µM, and compounds 2 and 3 showed moderate acetylcholinesterase (AChE) inhibitory activities, with IC50 values of 26.8 and 29.2 µM, respectively.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vasodilatadores
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Inibidores da Colinesterase
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Folhas de Planta
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Loganiaceae
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Alcaloides de Triptamina e Secologanina
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article