Escape from planarity in fragment-based drug discovery: A physicochemical and 3D property analysis of synthetic 3D fragment libraries.

Hamilton, David J; Dekker, Tom; Klein, Hanna F; Janssen, Guido V; Wijtmans, Maikel; O'Brien, Peter; de Esch, Iwan J P

Hamilton, David J; Dekker, Tom; Klein, Hanna F; Janssen, Guido V; Wijtmans, Maikel; O'Brien, Peter; de Esch, Iwan J P.

Afiliação

Hamilton DJ; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
Dekker T; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
Klein HF; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
Janssen GV; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
Wijtmans M; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
O'Brien P; Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
de Esch IJP; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. Electronic address: i.de.esch@vu.nl.

Drug Discov Today Technol ; 38: 77-90, 2020 Dec.

Article em En | MEDLINE | ID: mdl-34895643

Assuntos

Descoberta de Drogas; Bibliotecas de Moléculas Pequenas

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bibliotecas de Moléculas Pequenas / Descoberta de Drogas Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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