Film-like organelles equip cells with multiple genetic codes.

Taylor, Neil C; Nikic-Spiegel, Ivana

Taylor, Neil C; Nikic-Spiegel, Ivana.

Afiliação

Taylor NC; Centre for Integrative Neuroscience, University of Tübingen, Otfried-Müller-Straße 25, 72076 Tübingen, Germany.
Nikic-Spiegel I; Centre for Integrative Neuroscience, University of Tübingen, Otfried-Müller-Straße 25, 72076 Tübingen, Germany. Electronic address: ivana.nikic@cin.uni-tuebingen.deivana.nikic@cin.uni-tuebingen.de.

Trends Biochem Sci ; 47(5): 369-371, 2022 05.

Article em En | MEDLINE | ID: mdl-34895957

RESUMO

The simultaneous incorporation of distinct noncanonical amino acids into different proteins within eukaryotic cells remains challenging. This new study by Reinkemeierand Lemke demonstrates how 2D phase separation can be used to engineer spatially separated organelles. These film-like organelles translate proteins independently from each other and the canonical genetic code.

Assuntos

Código Genético; Organelas; Aminoácidos/metabolismo; Células Eucarióticas/metabolismo; Organelas/metabolismo; Proteínas/metabolismo

Palavras-chave

2D phase separation; enzyme engineering; genetic code expansion; noncanonical amino acid; synthetic biology; synthetic organelle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Organelas / Código Genético Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Organelas / Código Genético Idioma: En Ano de publicação: 2022 Tipo de documento: Article