Your browser doesn't support javascript.
loading
Assessment of left ventricular dyssynchrony by speckle tracking echocardiography in children with duchenne muscular dystrophy.
Lanot, Nicolas; Vincenti, Marie; Abassi, Hamouda; Bredy, Charlene; Agullo, Audrey; Gamon, Lucie; Mura, Thibault; Lavastre, Kathleen; De La Villeon, Gregoire; Barrea, Catherine; Meyer, Pierre; Rivier, François; Meli, Albano C; Fauconnier, Jeremy; Cazorla, Olivier; Lacampagne, Alain; Amedro, Pascal.
Afiliação
  • Lanot N; Paediatric and Adult Cardiology Department, M3C Regional Reference CHD Center, CHU Montpellier, Montpellier, France.
  • Vincenti M; Paediatric and Adult Cardiology Department, M3C Regional Reference CHD Center, CHU Montpellier, Montpellier, France.
  • Abassi H; PhyMedExp, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.
  • Bredy C; Paediatric and Adult Cardiology Department, M3C Regional Reference CHD Center, CHU Montpellier, Montpellier, France.
  • Agullo A; PhyMedExp, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.
  • Gamon L; Paediatric and Adult Cardiology Department, M3C Regional Reference CHD Center, CHU Montpellier, Montpellier, France.
  • Mura T; Paediatric and Adult Cardiology Department, M3C Regional Reference CHD Center, CHU Montpellier, Montpellier, France.
  • Lavastre K; Epidemiology and Clinical Research Department, CHU Montpellier, Montpellier, France.
  • De La Villeon G; Epidemiology and Clinical Research Department, CHU Nimes, Nimes, France.
  • Barrea C; Paediatric and Adult Cardiology Department, M3C Regional Reference CHD Center, CHU Montpellier, Montpellier, France.
  • Meyer P; Paediatric and Adult Cardiology Department, M3C Regional Reference CHD Center, CHU Montpellier, Montpellier, France.
  • Rivier F; Paediatric Cardiology and Rehabilitation Unit, Saint-Pierre Institute, Palavas-Les-Flots, France.
  • Meli AC; Paediatric and Congenital Cardiology Department, Cliniques Universitaires Saint-Luc, UCL University, Brussels, Belgium.
  • Fauconnier J; PhyMedExp, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.
  • Cazorla O; Paediatric Neurology, National Reference Center for Neuromuscular Diseases, CHU Montpellier, Montpellier, France.
  • Lacampagne A; PhyMedExp, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.
  • Amedro P; Paediatric Neurology, National Reference Center for Neuromuscular Diseases, CHU Montpellier, Montpellier, France.
Int J Cardiovasc Imaging ; 38(1): 79-89, 2022 Jan.
Article em En | MEDLINE | ID: mdl-34905152
ABSTRACT
Prognosis of Duchenne muscular dystrophy (DMD) is related to cardiac dysfunction. Two dimensional-speckle tracking echocardiography (2D-STE) has recently emerged as a non-invasive functional biomarker for early detection of DMD-related cardiomyopathy. This study aimed to determine, in DMD children, the existence of left ventricle (LV) dyssynchrony using 2D-STE analysis. This prospective controlled study enrolled 25 boys with DMD (mean age 11.0 ± 3.5 years) with normal LV ejection fraction and 50 age-matched controls. Three measures were performed to assess LV mechanical dyssynchrony the opposing-wall delays (longitudinal and radial analyses), the modified Yu index, and the time-to-peak delays of each segment. Feasibility and reproducibility of 2D-STE dyssynchrony were evaluated. All three mechanical dyssynchrony criteria were significantly higher in the DMD group than in healthy

subjects:

(1) opposing-wall delays in basal inferoseptal to basal anterolateral segments (61.4 ± 45.3 ms vs. 18.3 ± 50.4 ms, P < 0.001, respectively) and in mid inferoseptal to mid anterolateral segments (58.6 ± 35.3 ms vs. 42.4 ± 36.4 ms, P < 0.05, respectively), (2) modified Yu index (33.3 ± 10.1 ms vs. 28.5 ± 8.1 ms, P < 0.05, respectively), and (3) most of time-to-peak values, especially in basal and mid anterolateral segments. Feasibility was excellent and reliability was moderate to excellent, with ICC values ranging from 0.49 to 0.97. Detection of LV mechanical dyssynchrony using 2D-STE analysis is an easily and reproducible method in paediatric DMD. The existence of an early LV mechanical dyssynchrony visualized using 2D-STE analysis in children with DMD before the onset of cardiomyopathy represents a perspective for future paediatric drug trials in the DMD-related cardiomyopathy prevention.Clinical Trial Registration Clinicaltrials.gov NCT02418338. Post-hoc study, registered on April 16, 2015.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Disfunção Ventricular Esquerda / Distrofia Muscular de Duchenne Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Child / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Disfunção Ventricular Esquerda / Distrofia Muscular de Duchenne Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Child / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article