Interleukins in adipose tissue: Keeping the balance.
Mol Cell Endocrinol
; 542: 111531, 2022 02 15.
Article
em En
| MEDLINE
| ID: mdl-34910978
ABSTRACT
The role of the immune system is to defend the host and preserve the functionality in response to stress. This function is not limited to infection or injury as it also plays a role in the response to overnutrition. Indeed, low-grade chronic activation of the immune system associated with overnutrition may be deleterious, contributing importantly to diabetes and long-term complications, such as cardiovascular disorders. Increasing evidence shows that adipose tissue participates in the obesity-related inflammatory response and that interleukins are one of the key players, either as a pro-inflammatory response to the metabolic dysregulation or to restore homeostasis. The crosstalk between adipocytes and immune cells through some important interleukins and their role in metabolic disruption is the topic of this review.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article