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Humanized Patient-Derived Xenograft Models of Ovarian Cancer.
Gitto, Sarah B; George, Erin; Medvedev, Sergey; Simpkins, Fiona; Powell, Daniel J.
Afiliação
  • Gitto SB; Cancer Research Center, Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • George E; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA, USA.
  • Medvedev S; Ovarian Cancer Research Center, Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Simpkins F; Ovarian Cancer Research Center, Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Powell DJ; Ovarian Cancer Research Center, Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Methods Mol Biol ; 2424: 255-274, 2022.
Article em En | MEDLINE | ID: mdl-34918300
ABSTRACT
In vivo modeling of cancer is a critical step in testing novel therapeutic strategies to advance patient care. Here we describe how to develop a humanized patient-derived xenograft (PDX) model of ovarian cancer that uses orthotopically transplanted patient ovarian tumors with autologous transfer of expanded tumor infiltrating T cells (TILs) as a model that can be utilized to test immunomodulating therapeutics in vivo.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Linfócitos do Interstício Tumoral Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Linfócitos do Interstício Tumoral Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article