Evidence for monoclonal T lymphocyte proliferation in angioimmunoblastic lymphadenopathy.
J Clin Pathol
; 39(11): 1229-32, 1986 Nov.
Article
em En
| MEDLINE
| ID: mdl-3491840
ABSTRACT
The arrangement of the T cell receptor and immunoglobulin genes was analysed in lymphoid tissue biopsy specimens from 25 cases of angioimmunoblastic lymphadenopathy. Nineteen cases showed a rearrangement of the gene coding for the beta chain of the T cell receptor, and in one case a clonal rearrangement of immunoglobulin genes was shown (in which the T cell receptor gene was in a germline configuration). These findings indicate that a monoclonal T cell proliferation is present in most cases of angioimmunoblastic lymphadenopathy, and they also correlate with the fact that some patients who present with this disorder subsequently develop a T cell lymphoma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Linfócitos T
/
Linfadenopatia Imunoblástica
Limite:
Humans
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article