EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis.
Nat Commun
; 12(1): 7334, 2021 12 17.
Article
em En
| MEDLINE
| ID: mdl-34921133
ABSTRACT
The erythroid terminal differentiation program couples sequential cell divisions with progressive reductions in cell size. The erythropoietin receptor (EpoR) is essential for erythroblast survival, but its other functions are not well characterized. Here we use Epor-/- mouse erythroblasts endowed with survival signaling to identify novel non-redundant EpoR functions. We find that, paradoxically, EpoR signaling increases red cell size while also increasing the number and speed of erythroblast cell cycles. EpoR-regulation of cell size is independent of established red cell size regulation by iron. High erythropoietin (Epo) increases red cell size in wild-type mice and in human volunteers. The increase in mean corpuscular volume (MCV) outlasts the duration of Epo treatment and is not the result of increased reticulocyte number. Our work shows that EpoR signaling alters the relationship between cycling and cell size. Further, diagnostic interpretations of increased MCV should now include high Epo levels and hypoxic stress.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Receptores da Eritropoetina
/
Tamanho Celular
/
Eritrócitos
/
Eritropoese
Tipo de estudo:
Clinical_trials
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article