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Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11.
Jang, Jun-Pil; Jang, Mina; Hwang, Gwi Ja; Kim, Min Hee; Ahn, Jong Seog; Ko, Sung-Kyun; Jang, Jae-Hyuk.
Afiliação
  • Jang JP; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea.
  • Jang M; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea.
  • Hwang GJ; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, South Korea.
  • Kim MH; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea.
  • Ahn JS; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, South Korea. Electronic address: jsahn@kribb.re.kr.
  • Ko SK; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, South Korea. Electronic address: ksk1230@kribb.re.kr.
  • Jang JH; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea; Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, South Korea. Electronic address: jangjh@kribb.re.kr.
Bioorg Med Chem Lett ; 57: 128504, 2022 02 01.
Article em En | MEDLINE | ID: mdl-34922027
Two new fusicoccane-type diterpenoids, streptooctatins A (1) and B (2), together with a known compound cyclooctatin (3) were isolated from Streptomyces sp. KCB17JA11. The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and HRESIMS experiments. Compounds 1 and 2 induced EGFP-LC3 puncta indicating autophagic activities against HeLa cells without cytotoxicity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Streptomyces / Diterpenos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Streptomyces / Diterpenos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article