Glyoxal damages human aortic endothelial cells by perturbing the glutathione, mitochondrial membrane potential, and mitogen-activated protein kinase pathways.

Xie, Ming-Zhang; Guo, Chun; Dong, Jia-Qi; Zhang, Jie; Sun, Ke-Tao; Lu, Guang-Jian; Wang, Lei; Bo, De-Ying; Jiao, Lu-Yang; Zhao, Guo-An

Xie, Ming-Zhang; Guo, Chun; Dong, Jia-Qi; Zhang, Jie; Sun, Ke-Tao; Lu, Guang-Jian; Wang, Lei; Bo, De-Ying; Jiao, Lu-Yang; Zhao, Guo-An.

Afiliação

Xie MZ; Department of Laboratory, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, People's Republic of China. 77128425@qq.com.
Guo C; Henan Key Laboratory of Neural Regeneration (Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia), First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, People's Republic of China.
Dong JQ; Department of Cardiovascular, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, People's Republic of China.
Zhang J; Department of Integrating Western and Chinese of Internal Medicine, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, People's Republic of China.
Sun KT; Department of Laboratory, Zibo Central Hospital, Zibo, 255036, Shandong, People's Republic of China.
Lu GJ; Department of Laboratory, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, People's Republic of China.
Wang L; Department of Laboratory, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, People's Republic of China.
Bo DY; Department of Laboratory, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, People's Republic of China.
Jiao LY; Department of Laboratory, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, People's Republic of China. jly@xxmu.edu.cn.
Zhao GA; Department of Cardiovascular, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453000, Henan, People's Republic of China. tougao3@sohu.com.

BMC Cardiovasc Disord ; 21(1): 603, 2021 12 18.

Article em En | MEDLINE | ID: mdl-34922451

Assuntos

Aorta/efeitos dos fármacos; Células Endoteliais/efeitos dos fármacos; Glutationa/metabolismo; Glioxal/toxicidade; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Mitocôndrias/efeitos dos fármacos; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Aorta/enzimologia; Aorta/patologia; Células Cultivadas; Dano ao DNA; Células Endoteliais/enzimologia; Células Endoteliais/patologia; Humanos; Mitocôndrias/enzimologia; Mitocôndrias/patologia; Estresse Oxidativo/efeitos dos fármacos; Fosforilação; Transdução de Sinais; Tiorredoxinas/metabolismo

Palavras-chave

Cardiovascular diseases; Glyoxal; Human aortic endothelial cells; Laboratory indexes; Mitogen-activated protein kinase pathways

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aorta / Proteínas Quinases Ativadas por Mitógeno / Células Endoteliais / Potencial da Membrana Mitocondrial / Glutationa / Glioxal / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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