Substituents of life: The most common substituent patterns present in natural products.
Bioorg Med Chem
; 54: 116562, 2022 01 15.
Article
em En
| MEDLINE
| ID: mdl-34923390
ABSTRACT
Comparison of substituents present in natural products with the substituents found in average synthetic molecules reveals considerable differences between these two groups. The natural products substituents contain mostly oxygen heteroatoms, are structurally more complex, often containing double bonds and are rich in stereocenters. Substituents found in synthetic molecules contain nitrogen and sulfur heteroatoms, halogenes and more aromatic and particularly heteroaromatic rings. The characteristics of substituents typical for natural products identified here can be useful in the medicinal chemistry context, for example to guide the synthesis of natural product-like libraries and natural product-inspired fragment collections. The results may be used also to support compound derivatization strategies and the design of pseudo-natural natural products.
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Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Desenho de Fármacos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article