Risk Factors for Severe COVID-19 in Children.
Pediatrics
; 149(1)2022 01 01.
Article
em En
| MEDLINE
| ID: mdl-34935038
ABSTRACT
OBJECTIVES:
Describe population-based rates and risk factors for severe coronavirus disease 2019 (COVID-19) (ie, ICU admission, invasive mechanical ventilation, or death) among hospitalized children.METHODS:
During March 2020 to May 2021, the COVID-19-Associated Hospitalization Surveillance Network identified 3106 children hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection in 14 states. Among 2293 children primarily admitted for COVID-19, multivariable generalized estimating equations generated adjusted risk ratios (aRRs) and 95% confidence intervals (CIs) of the associations between demographic and medical characteristics abstracted from medical records and severe COVID-19. We calculated age-adjusted cumulative population-based rates of severe COVID-19 among all children.RESULTS:
Approximately 30% of hospitalized children had severe COVID-19; 0.5% died during hospitalization. Among hospitalized children aged <2 years, chronic lung disease (aRR 2.2; 95% CI 1.1-4.3), neurologic disorders (aRR 2.0; 95% CI 1.5â2.6), cardiovascular disease (aRR 1.7; 95% CI 1.2â2.3), prematurity (aRR 1.6; 95% CI 1.1â2.2), and airway abnormality (aRR 1.6; 95% CI 1.1â2.2) were associated with severe COVID-19. Among hospitalized children aged 2 to 17 years, feeding tube dependence (aRR 2.0; 95% CI 1.5â2.5), diabetes mellitus (aRR 1.9; 95% CI 1.6â2.3) and obesity (aRR 1.2; 95% CI 1.0â1.4) were associated with severe COVID-19. Severe COVID-19 occurred among 12.0 per 100 000 children overall and was highest among infants, Hispanic children, and non-Hispanic Black children.CONCLUSIONS:
Results identify children at potentially higher risk of severe COVID-19 who may benefit from prevention efforts, including vaccination. Rates establish a baseline for monitoring changes in pediatric illness severity after increased availability of COVID-19 vaccines and the emergence of new variants.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
COVID-19
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Humans
/
Infant
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article