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Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides.
Zietzer, Andreas; Jahnel, Alina Lisann; Bulic, Marko; Gutbrod, Katharina; Düsing, Philip; Hosen, Mohammed Rabiul; Dörmann, Peter; Werner, Nikos; Nickenig, Georg; Jansen, Felix.
Afiliação
  • Zietzer A; Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. andreas.zietzer@ukbonn.de.
  • Jahnel AL; Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Bulic M; Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Gutbrod K; Institute of Molecular Physiology and Biotechnology of Plants, University of Bonn, Karlrobert-Kreiten-Str. 13, 53115, Bonn, Germany.
  • Düsing P; Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Hosen MR; Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Dörmann P; Institute of Molecular Physiology and Biotechnology of Plants, University of Bonn, Karlrobert-Kreiten-Str. 13, 53115, Bonn, Germany.
  • Werner N; Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
  • Nickenig G; Krankenhaus der Barmherzigen Brüder Trier, Nordallee 1, 54292, Trier, Germany.
  • Jansen F; Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Cell Mol Life Sci ; 79(1): 48, 2021 Dec 24.
Article em En | MEDLINE | ID: mdl-34951654
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esfingomielina Fosfodiesterase / Doenças das Artérias Carótidas / Ceramidas / Diabetes Mellitus Tipo 2 / Vesículas Extracelulares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esfingomielina Fosfodiesterase / Doenças das Artérias Carótidas / Ceramidas / Diabetes Mellitus Tipo 2 / Vesículas Extracelulares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article