MLH1 mediates cytoprotective nucleophagy to resist 5-Fluorouracil-induced cell death in colorectal carcinoma.

Manzoor, Shaista; Saber-Ayad, Maha; Maghazachi, Azzam A; Hamid, Qutayba; Muhammad, Jibran Sualeh

Manzoor, Shaista; Saber-Ayad, Maha; Maghazachi, Azzam A; Hamid, Qutayba; Muhammad, Jibran Sualeh.

Afiliação

Manzoor S; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Saber-Ayad M; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates. Electronic address: msaber@sharjah.ac.ae.
Maghazachi AA; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates.
Hamid Q; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates; Meakins-Christie Laboratories, Research Institute of the McGill University Health
Muhammad JS; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates; Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. Electronic address: dr.jibran@live.com.

Neoplasia ; 24(2): 76-85, 2022 02.

Article em En | MEDLINE | ID: mdl-34952246

Assuntos

Autofagia/efeitos dos fármacos; Autofagia/genética; Neoplasias Colorretais/genética; Citoproteção/genética; Fluoruracila/farmacologia; Proteína 1 Homóloga a MutL/genética; Morte Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Dano ao DNA/efeitos dos fármacos; Técnicas de Silenciamento de Genes; Humanos

Palavras-chave

Autophagy; CRISPR-Cas9; Chemoresistance; Colorectal cancer; LC3; Lamin; Microsatellite instability; Mismatch Repair; Nucleophagy; SIRT1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias Colorretais / Citoproteção / Fluoruracila / Proteína 1 Homóloga a MutL Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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