Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers.

Nakamura, Shinji; Kamaura, Masahiro; Akao, Yuichiro; Nakamura, Natsuko; Mizukami, Atsushi; Goto, Akihiko; Furuyama, Naoki; Cho, Nobuo; Kasai, Shizuo

Nakamura, Shinji; Kamaura, Masahiro; Akao, Yuichiro; Nakamura, Natsuko; Mizukami, Atsushi; Goto, Akihiko; Furuyama, Naoki; Cho, Nobuo; Kasai, Shizuo.

Afiliação

Nakamura S; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Kamaura M; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Akao Y; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Nakamura N; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Mizukami A; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Goto A; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Furuyama N; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Cho N; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Kasai S; Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: shizuo.kasai@axcelead.com.

Bioorg Med Chem ; 54: 116553, 2022 01 15.

Article em En | MEDLINE | ID: mdl-34953340

Assuntos

Descoberta de Drogas; Pirrolidinas/farmacologia; Proteínas Plasmáticas de Ligação ao Retinol/antagonistas & inibidores; Relação Dose-Resposta a Droga; Humanos; Estrutura Molecular; Pirrolidinas/síntese química; Pirrolidinas/química; Proteínas Plasmáticas de Ligação ao Retinol/metabolismo; Relação Estrutura-Atividade

Palavras-chave

Age-related macular degeneration (AMD); Diabetes; Proteinprotein interaction (PPI); Retinol-binding protein 4 (RBP4); Transthyretin (TTR)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolidinas / Proteínas Plasmáticas de Ligação ao Retinol / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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