Social participation is reduced in type 3 Von Willebrand disease patients and in patients with a severe bleeding phenotype.
Haemophilia
; 28(2): 278-285, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-34964530
ABSTRACT
INTRODUCTION:
The negative impact of haemophilia on social participation is well established in previous studies, however, the impact of Von Willebrand disease (VWD) on social participation has not been studied.AIM:
To compare the social participation of a large cohort of VWD patients in the Netherlands with the general Dutch population. In addition, to identify factors associated with social participation in VWD.METHODS:
Patients participating in the "Willebrand in the Netherlands" study completed an extensive questionnaire on educational level, absenteeism from school or work, and occupational disabilities.RESULTS:
Seven-hundred and eighty-eight VWD patients were included (mean age 38.9 years, 59.5% females), of whom 136 children < 16 years. Adult patients with type 3 VWD more often had a low educational level (52.9%) compared to type 1 (40.2%), type 2 VWD (36.8%) and the general population (36.4%) (p = .005). Moreover, in patients aged ≥16 years the days lost from school and/or work in the year prior to study inclusion differed significantly between the VWD types (p = .011). Using negative binomial regression analysis, the occurrence of bleeding episodes requiring treatment in the year preceding study inclusion was significantly associated with the number of days lost from school and/or work among patients aged ≥16 years. Multivariable logistic regression analysis showed that a higher total bleeding score, older age and presence of at least one comorbidity were significantly associated with occupational disability in patients aged ≥16 years.CONCLUSION:
Our study shows that social participation was lower in type 3 VWD and VWD patients with a more severe bleeding phenotype.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças de von Willebrand
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Doença de von Willebrand Tipo 1
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Doença de von Willebrand Tipo 3
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article