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Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders.
Camuso, Serena; La Rosa, Piergiorgio; Fiorenza, Maria Teresa; Canterini, Sonia.
Afiliação
  • Camuso S; Division of Neuroscience, Dept. of Psychology, University La Sapienza, Rome, Italy; PhD Program in Behavioral Neuroscience, Sapienza University of Rome, Rome, Italy.
  • La Rosa P; Division of Neuroscience, Dept. of Psychology, University La Sapienza, Rome, Italy.
  • Fiorenza MT; Division of Neuroscience, Dept. of Psychology, University La Sapienza, Rome, Italy; IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00179 Rome, Italy.
  • Canterini S; Division of Neuroscience, Dept. of Psychology, University La Sapienza, Rome, Italy. Electronic address: sonia.canterini@uniroma1.it.
Neurobiol Dis ; 163: 105606, 2022 02.
Article em En | MEDLINE | ID: mdl-34974125
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the mammalian brain, essential not only to the development of the central nervous system but also to synaptic plasticity. BDNF is present in various brain areas, but highest levels of expression are seen in the cerebellum and hippocampus. After birth, BDNF acts in the cerebellum as a mitogenic and chemotactic factor, stimulating the cerebellar granule cell precursors to proliferate, migrate and maturate, while in the hippocampus BDNF plays a fundamental role in synaptic transmission and plasticity, representing a key regulator for the long-term potentiation, learning and memory. Furthermore, the expression of BDNF is highly regulated and changes of its expression are associated with both physiological and pathological conditions. The purpose of this review is to provide an overview of the current state of knowledge on the BDNF biology and its neurotrophic role in the proper development and functioning of neurons and synapses in two important brain areas of postnatal neurogenesis, the cerebellum and hippocampus. Dysregulation of BDNF expression and signaling, resulting in alterations in neuronal maturation and plasticity in both systems, is a common hallmark of several neurodevelopmental diseases, such as autism spectrum disorder, suggesting that neuronal malfunction present in these disorders is the result of excessive or reduced of BDNF support. We believe that the more the relevance of the pathophysiological actions of BDNF, and its downstream signals, in early postnatal development will be highlighted, the more likely it is that new neuroprotective therapeutic strategies will be identified in the treatment of various neurodevelopmental disorders.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cerebelo / Fator Neurotrófico Derivado do Encéfalo / Transtorno do Espectro Autista / Hipocampo / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cerebelo / Fator Neurotrófico Derivado do Encéfalo / Transtorno do Espectro Autista / Hipocampo / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article