The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology.
Front Immunol
; 12: 799861, 2021.
Article
em En
| MEDLINE
| ID: mdl-34975914
ABSTRACT
Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has been linked to immune evasion and metastatic spread, eventually by interaction with sialoglycan-binding lectins, including Siglecs and selectins. The biosynthesis of tumor-associated sialoglycans involves sialyltransferases, which are differentially expressed in cancer cells. In this review article, we provide an overview of the twenty human sialyltransferases and their roles in cancer biology and immunity. A better understanding of the individual contribution of select sialyltransferases to the tumor sialome may lead to more personalized strategies for the treatment of cancer.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Siálicos
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Sialiltransferases
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Selectinas
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Lectinas Semelhantes a Imunoglobulina de Ligação ao Ácido Siálico
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article