Perforated Duodenal Ulcer Associated with Deferasirox in a Child with ß-Thalassemia Major.
Hemoglobin
; 45(5): 335-337, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-34979847
ABSTRACT
The oral iron chelator, deferasirox (DFX), is commonly associated with mild gastrointestinal (GI) complaints, but GI hemorrhage and ulcers have occasionally been reported. However, perforated duodenal ulcer (PDU) has been previously reported in only one patient with ß-thalassemia major (ß-TM) on Exjade (DFXE). We hereby report the second case of a 5-year-old Syrian patient, who recently presented with PDU while on DFXE. She was not on any other ulcerogenic medication and was negative for H. pylori and Celiac disease. She had a surgical repair and has done well. She is back on DFX, but with the film-coated tablet, Jadenu or DFXJ. Perforated duodenal ulcer should be suspected in patients with severe GI symptoms, abdominal distension and tenderness while on DFXE, especially at high doses (30+ mg/kg).
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Talassemia beta
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Sobrecarga de Ferro
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Úlcera Duodenal
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Child
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Child, preschool
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Female
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article