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The profibrotic and senescence phenotype of old lung fibroblasts is reversed or ameliorated by genetic and pharmacological manipulation of Slc7a11 expression.
Ritzenthaler, Jeffrey D; Torres-Gonzalez, Edilson; Zheng, Yuxuan; Zelko, Igor N; van Berkel, Victor; Nunley, David R; Kidane, Biniam; Halayko, Andrew J; Summer, Ross; Watson, Walter H; Roman, Jesse.
Afiliação
  • Ritzenthaler JD; Division of Pulmonary, Allergy & Critical Care, Department of Medicine, Center for Translational Medicine, The Jane & Leonard Korman Respiratory Institute, Philadelphia, Pennsylvania.
  • Torres-Gonzalez E; Division of Pulmonary, Allergy & Critical Care, Department of Medicine, Center for Translational Medicine, The Jane & Leonard Korman Respiratory Institute, Philadelphia, Pennsylvania.
  • Zheng Y; Department of Pharmacology & Toxicology, University of Louisville, Louisville, Kentucky.
  • Zelko IN; Division of Environmental Medicine, Department of Medicine, University of Louisville, Louisville, Kentucky.
  • van Berkel V; Department of Thoracic Surgery, Lung Transplantation Program, University of Louisville, Louisville, Kentucky.
  • Nunley DR; Department of Medicine, Lung Transplantation Program, Ohio State University, Columbus, Ohio.
  • Kidane B; Section of Thoracic Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Halayko AJ; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Summer R; Division of Pulmonary, Allergy & Critical Care, Department of Medicine, Center for Translational Medicine, The Jane & Leonard Korman Respiratory Institute, Philadelphia, Pennsylvania.
  • Watson WH; Department of Pharmacology & Toxicology, University of Louisville, Louisville, Kentucky.
  • Roman J; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky.
Am J Physiol Lung Cell Mol Physiol ; 322(3): L449-L461, 2022 03 01.
Article em En | MEDLINE | ID: mdl-34984918
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar Idiopática / Fibroblastos Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar Idiopática / Fibroblastos Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article