Hemin-Induced Death Models Hemorrhagic Stroke and Is a Variant of Classical Neuronal Ferroptosis.

Zille, Marietta; Oses-Prieto, Juan A; Savage, Sara R; Karuppagounder, Saravanan S; Chen, Yingxin; Kumar, Amit; Morris, John H; Scheidt, Karl A; Burlingame, Alma L; Ratan, Rajiv R

Zille, Marietta; Oses-Prieto, Juan A; Savage, Sara R; Karuppagounder, Saravanan S; Chen, Yingxin; Kumar, Amit; Morris, John H; Scheidt, Karl A; Burlingame, Alma L; Ratan, Rajiv R.

Afiliação

Zille M; Burke Neurological Institute, White Plains, New York 10605 marietta.zille@univie.ac.at rrr2001@med.cornell.edu.
Oses-Prieto JA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Savage SR; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Vienna 1090, Austria.
Karuppagounder SS; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158.
Chen Y; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030.
Kumar A; Burke Neurological Institute, White Plains, New York 10605.
Morris JH; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Scheidt KA; Burke Neurological Institute, White Plains, New York 10605.
Burlingame AL; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10065.
Ratan RR; Burke Neurological Institute, White Plains, New York 10605.

J Neurosci ; 42(10): 2065-2079, 2022 03 09.

Article em En | MEDLINE | ID: mdl-34987108

Assuntos

Ferroptose; Acidente Vascular Cerebral Hemorrágico; Animais; Antioxidantes/metabolismo; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Glutationa/metabolismo; Hemina/metabolismo; Hemina/farmacologia; Hemoglobinas/metabolismo; Hemorragias Intracranianas/metabolismo; Ferro/metabolismo; Masculino; Camundongos; Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo; Necrose/metabolismo; Neurônios/metabolismo; Fosforilação

Palavras-chave

MAP signaling; brain hemorrhage; cell death; ferroptosis; phosphoproteomics; stroke

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ferroptose / Acidente Vascular Cerebral Hemorrágico Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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