Study of the DBA/2Ha immunodeficiency: X-chromosome mosaicism and in vivo immunoresponses.
Immunol Lett
; 15(3): 179-85, 1987 Jul.
Article
em En
| MEDLINE
| ID: mdl-3499386
ABSTRACT
DBA/2Ha mice have an X-chromosome-linked immunodeficiency and lack the receptor to a TRF (T cell replacing factor) on a subpopulation of B cells. Their immunodeficiency is considered to resemble that of CBA/N, another X-chromosome-linked immunodeficiency. To facilitate direct comparisons of the two immunodeficiencies and to study the in vivo manifestations of DBA/2Ha immunodeficiency, we measured phenotypes and functions of B cells of DBA/2Ha mice. We found that the expression of sIgM among B cells is normal in DBA/2Ha mice, heterozygous females equally express both affected and normal B cell subpopulations, and DBA/2Ha mice respond well to a TI-2 antigen (TNP-Ficoll) and a polyclonal activator (LPS). Unlike CBA/N, DBA/2Ha mice demonstrate very little in vivo immunodeficiencies.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomo X
/
Linfócitos
/
Receptores Imunológicos
/
Interleucinas
/
Síndromes de Imunodeficiência
/
Camundongos Endogâmicos DBA
Limite:
Animals
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article