Late-life physical activity relates to brain tissue synaptic integrity markers in older adults.
Alzheimers Dement
; 18(11): 2023-2035, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-34994517
ABSTRACT
INTRODUCTION:
Physical activity (PA) is widely recommended for age-related brain health, yet its neurobiology is not well understood. Animal models indicate PA is synaptogenic. We examined the relationship between PA and synaptic integrity markers in older adults.METHODS:
Four hundred four decedents from the Rush Memory and Aging Project completed annual actigraphy monitoring (Mean visits = 3.5±2.4) and post mortem evaluation. Brain tissue was analyzed for presynaptic proteins (synaptophysin, synaptotagmin-1, vesicle-associated membrane proteins, syntaxin, complexin-I, and complexin-II), and neuropathology. Models examined relationships between late-life PA (averaged across visits), and timing-specific PA (time to autopsy) with synaptic proteins.RESULTS:
Greater late-life PA associated with higher presynaptic protein levels (0.14 < ß < 0.20), except complexin-II (ß = 0.08). Relationships were independent of pathology but timing specific; participants who completed actigraphy within 2 years of brain tissue measurements showed largest PA-to-synaptic protein associations (0.32 < ß < 0.38). Relationships between PA and presynaptic proteins were comparable across brain regions sampled.DISCUSSION:
PA associates with synaptic integrity in a regionally global, but time-linked nature in older adults.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Exercício Físico
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article