Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction.

Vukicevic, Slobodan; Colliva, Andrea; Kufner, Vera; Martinelli, Valentina; Moimas, Silvia; Vodret, Simone; Rumenovic, Viktorija; Milosevic, Milan; Brkljacic, Boris; Delic-Brkljacic, Diana; Correa, Ricardo; Giacca, Mauro; Maglione, Manuel; Bordukalo-Niksic, Tatjana; Dumic-Cule, Ivo; Zacchigna, Serena

Vukicevic, Slobodan; Colliva, Andrea; Kufner, Vera; Martinelli, Valentina; Moimas, Silvia; Vodret, Simone; Rumenovic, Viktorija; Milosevic, Milan; Brkljacic, Boris; Delic-Brkljacic, Diana; Correa, Ricardo; Giacca, Mauro; Maglione, Manuel; Bordukalo-Niksic, Tatjana; Dumic-Cule, Ivo; Zacchigna, Serena.

Afiliação

Vukicevic S; Laboratory for Mineralized Tissues, Center for Translational and Clinical Research, University of Zagreb School of Medicine, Zagreb, Croatia.
Colliva A; Cardiovascular Biology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Kufner V; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Martinelli V; Laboratory for Mineralized Tissues, Center for Translational and Clinical Research, University of Zagreb School of Medicine, Zagreb, Croatia.
Moimas S; Molecular Medicine, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Vodret S; Molecular Medicine, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Rumenovic V; Cardiovascular Biology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Milosevic M; Laboratory for Mineralized Tissues, Center for Translational and Clinical Research, University of Zagreb School of Medicine, Zagreb, Croatia.
Brkljacic B; Department for Environmental Health and Occupational and Sports Medicine, University of Zagreb School of Medicine, Zagreb, Croatia.
Delic-Brkljacic D; Department of Diagnostic and Interventional Radiology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia.
Correa R; Department of Cardiology, Clinical Hospital Sisters of Mercy, University of Zagreb School of Medicine, Zagreb, Croatia.
Giacca M; Cardiovascular Biology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Maglione M; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Bordukalo-Niksic T; Molecular Medicine, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Dumic-Cule I; School of Cardiovascular Medicine & Sciences, King's College London, London, UK.
Zacchigna S; Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria.

Nat Commun ; 13(1): 81, 2022 01 10.

Article em En | MEDLINE | ID: mdl-35013172

Assuntos

Anticorpos Monoclonais/farmacologia; Proteína Morfogenética Óssea 1/genética; Cardiotônicos/farmacologia; Cicatriz/genética; Fibrose Endomiocárdica/genética; Infarto do Miocárdio/genética; Animais; Proteína Morfogenética Óssea 1/antagonistas & inibidores; Proteína Morfogenética Óssea 1/metabolismo; Proteína Morfogenética Óssea 2/genética; Proteína Morfogenética Óssea 2/metabolismo; Proteína Morfogenética Óssea 5/genética; Proteína Morfogenética Óssea 5/metabolismo; Estudos de Casos e Controles; Sobrevivência Celular/efeitos dos fármacos; Cicatriz/etiologia; Cicatriz/metabolismo; Cicatriz/prevenção & controle; Modelos Animais de Doenças; Fibrose Endomiocárdica/etiologia; Fibrose Endomiocárdica/metabolismo; Fibrose Endomiocárdica/prevenção & controle; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Fibroblastos/patologia; Regulação da Expressão Gênica; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Infarto do Miocárdio/complicações; Infarto do Miocárdio/metabolismo; Miócitos Cardíacos/efeitos dos fármacos; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/patologia; Cultura Primária de Células; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Ratos; Ratos Sprague-Dawley; Transdução de Sinais; Fator de Crescimento Transformador beta/genética; Fator de Crescimento Transformador beta/metabolismo; Troponina T/genética; Troponina T/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cardiotônicos / Cicatriz / Fibrose Endomiocárdica / Proteína Morfogenética Óssea 1 / Anticorpos Monoclonais / Infarto do Miocárdio Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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