Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine.
Nat Commun
; 13(1): 234, 2022 01 11.
Article
em En
| MEDLINE
| ID: mdl-35017515
ABSTRACT
Environmental enteric dysfunction is associated with malnutrition as well as infant growth stunting and has been classically defined by villous blunting, decreased crypt-to-villus ratio, and inflammation in the small intestine. Here, we characterized environmental enteric dysfunction among infant rhesus macaques that are naturally exposed to enteric pathogens commonly linked to human growth stunting. Remarkably, despite villous atrophy and histological abnormalities observed in the small intestine, poor growth trajectories and low serum tryptophan levels were correlated with increased histopathology in the large intestine. This work provides insight into the mechanisms underlying this disease and indicates that the large intestine may be an important target for therapeutic intervention.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Intestino Grosso
/
Intestino Delgado
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Macaca mulatta
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article