Natural History of Incident and Persistent Cutaneous Human Papillomavirus and Human Polyomavirus Infections.
J Infect Dis
; 226(7): 1162-1174, 2022 09 28.
Article
em En
| MEDLINE
| ID: mdl-35022780
ABSTRACT
BACKGROUND:
Cutaneous human papillomaviruses (cuHPV) and polyomaviruses (HPyV) have been implicated in skin cancers; however, interpretation of findings across studies is complicated by limited understanding of the natural history of these infections across normal tissue types.METHODS:
In total, 675 eyebrow hair (EBH) and skin swab (SSW) samples were collected from 71 skin cancer screening patients every 6 months over 2 years and measured for presence of ß-HPV, γ-HPV, and HPyV. Incidence, persistence, and clearance of cuHPV/HPyV were estimated, and risk factors associated with infection were examined.RESULTS:
Prevalence, incidence, and persistence of ß-HPV, γ-HPV, and HPyV were consistently higher in SSW than in EBH, with types 5, 24, 49, 76 and Merkel cell polyomavirus (MCPyV) having incidence rates greater than 20 per 1000 person-months. Prevalent γ-HPV EBH infections persisted more often in women (Pâ =â .024), incident ß-HPV EBH infections persisted less often among individuals with history of blistering sunburn (Pâ =â .019), and prevalent MCPyV SSW infections persisted more often in those with a history of skin cancer (Pâ =â .033).CONCLUSIONS:
Incidence and persistence of cuHPV/HPyV were observed in SSW and EBH; however, none of the risk factors examined were commonly associated with cuHPV/HPyV infections across normal tissue types.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Polyomavirus
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Infecções por Papillomavirus
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Infecções por Polyomavirus
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Alphapapillomavirus
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article