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Angiotensin II infusion in COVID-19: An international, multicenter, registry-based study.
Serpa Neto, Ary; Landoni, Giovanni; Ostermann, Marlies; Lumlertgul, Nuttha; Forni, Lui; Alvarez-Belon, Lucas; Trapani, Tony; Alliegro, Patricia V; Zacharowski, Kai; Wiedenbeck, Carolin; de Backer, Daniel; Bellomo, Rinaldo.
Afiliação
  • Serpa Neto A; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
  • Landoni G; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Ostermann M; Department of Critical Care, University of Melbourne, Melbourne, Australia.
  • Lumlertgul N; Data Analytics Research and Evaluation (DARE) Centre, Austin Hospital, Melbourne, Australia.
  • Forni L; Department of Intensive Care and Anesthesiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Alvarez-Belon L; Vita-Salute San Raffaele University, Milan, Italy.
  • Trapani T; Department of Critical Care, Guys & St Thomas' Foundation Trust, London, UK.
  • Alliegro PV; Department of Critical Care, Guys & St Thomas' Foundation Trust, London, UK.
  • Zacharowski K; Department of Intensive Care, Royal Surrey County Hospital NHS Foundation Trust, Surrey, UK.
  • Wiedenbeck C; Department of Intensive Care, Royal Surrey County Hospital NHS Foundation Trust, Surrey, UK.
  • de Backer D; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
  • Bellomo R; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
J Med Virol ; 94(5): 2079-2088, 2022 05.
Article em En | MEDLINE | ID: mdl-35029318
To expand our understanding of the role of angiotensin II (ANGII) in coronavirus infectious disease 2019 (COVID-19), we conducted an international, multicenter registry study to assess the use of ANGII in patients with COVID-19 compared to patients not receiving ANGII. Critically ill adult patients who were diagnosed with COVID-19 and received ANGII were matched with COVID-19 patients not receiving ANGII according to age, respiratory support, history of hypertension, use of angiotensin-converting enzyme inhibitors and/or ANGII receptor blocker, and date of admission. All outcomes were exploratory in nature and included improvement in oxygenation, duration of organ support, and mortality. In one year, 132 patients were included (65 in the ANGII group and 67 in the control group), and patients were comparable in baseline characteristics. During the first 12 h of infusion, patients in the ANGII had a faster decrease in FiO2  and maintained similar mean arterial pressure levels. Hospital mortality was not statistically significantly different between the groups (53.8% vs. 40.3%; p = 0.226). Within the limitations of such a study design, our findings confirm previous observations of a potentially positive effect of ANGII on blood pressure and FiO2 but no effect on patient-centered outcomes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Transmissíveis / Tratamento Farmacológico da COVID-19 Tipo de estudo: Clinical_trials Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Transmissíveis / Tratamento Farmacológico da COVID-19 Tipo de estudo: Clinical_trials Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article