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Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers.
Smith, Christopher R; Aranda, Ruth; Bobinski, Thomas P; Briere, David M; Burns, Aaron C; Christensen, James G; Clarine, Jeffery; Engstrom, Lars D; Gunn, Robin J; Ivetac, Anthony; Jean-Baptiste, Ronald; Ketcham, John M; Kobayashi, Masakazu; Kuehler, Jon; Kulyk, Svitlana; Lawson, J David; Moya, Krystal; Olson, Peter; Rahbaek, Lisa; Thomas, Nicole C; Wang, Xiaolun; Waters, Laura M; Marx, Matthew A.
Afiliação
  • Smith CR; Mirati Therapeutics, San Diego, California 92121, United States.
  • Aranda R; Mirati Therapeutics, San Diego, California 92121, United States.
  • Bobinski TP; DSG, San Diego, California 92130, United States.
  • Briere DM; Mirati Therapeutics, San Diego, California 92121, United States.
  • Burns AC; Mirati Therapeutics, San Diego, California 92121, United States.
  • Christensen JG; Mirati Therapeutics, San Diego, California 92121, United States.
  • Clarine J; Mirati Therapeutics, San Diego, California 92121, United States.
  • Engstrom LD; Mirati Therapeutics, San Diego, California 92121, United States.
  • Gunn RJ; Mirati Therapeutics, San Diego, California 92121, United States.
  • Ivetac A; Mirati Therapeutics, San Diego, California 92121, United States.
  • Jean-Baptiste R; ZoBio BV, J. H. Oortweg 19, 2333 CH Leiden, Netherlands.
  • Ketcham JM; Mirati Therapeutics, San Diego, California 92121, United States.
  • Kobayashi M; ZoBio BV, J. H. Oortweg 19, 2333 CH Leiden, Netherlands.
  • Kuehler J; Mirati Therapeutics, San Diego, California 92121, United States.
  • Kulyk S; Mirati Therapeutics, San Diego, California 92121, United States.
  • Lawson JD; Mirati Therapeutics, San Diego, California 92121, United States.
  • Moya K; Mirati Therapeutics, San Diego, California 92121, United States.
  • Olson P; Mirati Therapeutics, San Diego, California 92121, United States.
  • Rahbaek L; Mirati Therapeutics, San Diego, California 92121, United States.
  • Thomas NC; Mirati Therapeutics, San Diego, California 92121, United States.
  • Wang X; Mirati Therapeutics, San Diego, California 92121, United States.
  • Waters LM; Mirati Therapeutics, San Diego, California 92121, United States.
  • Marx MA; Mirati Therapeutics, San Diego, California 92121, United States.
J Med Chem ; 65(3): 1749-1766, 2022 02 10.
Article em En | MEDLINE | ID: mdl-35041419
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalazinas / Proteína-Arginina N-Metiltransferases / Neoplasias / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalazinas / Proteína-Arginina N-Metiltransferases / Neoplasias / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article