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Prognostic factors of overall survival in patients with recurrent disease following liver resection for colorectal cancer metastases: A multicenter external validation study.
Park, Lily J; Daza, Julian F; Li, Vivian; Workneh, Aklile; Zuk, Victoria; Claasen, Marco P A; Hallet, Julie; Martel, Guillaume; Sapisochin, Gonzalo; Serrano, Pablo E.
Afiliação
  • Park LJ; Division of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
  • Daza JF; Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Li V; Division of General Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
  • Workneh A; Liver and Pancreas Unit, Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, Canada.
  • Zuk V; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
  • Claasen MPA; Division of General Surgery, Sunnybrook Health Sciences Centre-Odette Cancer Centre, Toronto, Ontario, Canada.
  • Hallet J; Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Martel G; Department of Surgery, Division of HPB and Transplant Surgery, Erasmus MC Transplant Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
  • Sapisochin G; Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Serrano PE; Division of General Surgery, Sunnybrook Health Sciences Centre-Odette Cancer Centre, Toronto, Ontario, Canada.
J Surg Oncol ; 125(5): 872-879, 2022 Apr.
Article em En | MEDLINE | ID: mdl-35050522
BACKGROUND: The clinical course of patients experiencing recurrence following hepatectomy for colorectal cancer metastases (CRM) is poorly defined. Previous studies associated shorter time to recurrence (TTR) in months, node-positive primary tumor, and more than one site of recurrence with worse outcomes. METHODS: We conducted a retrospective cohort study across four Canadian institutions to externally validate previously established prognostic factors of overall survival (OS). We included consecutive adult patients who had a recurrence following curative-intent liver resection for CRM. Prognostic factors were explored using a multivariable Cox regression model. Risk group cutoffs were identified through recursive partitioning. OS between low- and high-risk groups was compared using the Kaplan-Meier method. RESULTS: This study included 471 patients. Shorter TTR in months (hazard ratio [HR]: 0.95, 95% confidence interval [CI]: 0.93-0.97), presence of extrahepatic disease at first hepatectomy (HR: 2.54, 95% CI: 1.18-5.50), and larger tumor size in millimetres (HR: 1.01, 95% CI: 1.00-1.02) were associated with worse OS. Median OS in the high- and low-risk groups were 40.5 (95% CI: 34.0-45.7 months) versus 64.7 months (95% CI: 57.9-72.3 months; p < 0.001), respectively. CONCLUSIONS: We externally validated the prognostic significance of shorter TTR (<8.5 months) as a predictor of worse OS in patients who recur the following hepatectomy for CRM.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Neoplasias Hepáticas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans País como assunto: America do norte Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Neoplasias Hepáticas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans País como assunto: America do norte Idioma: En Ano de publicação: 2022 Tipo de documento: Article