Advances in Allogeneic Cancer Cell Therapy and Future Perspectives on "Off-the-Shelf" T Cell Therapy Using iPSC Technology and Gene Editing.
Cells
; 11(2)2022 01 13.
Article
em En
| MEDLINE
| ID: mdl-35053386
ABSTRACT
The concept of allogeneic cell therapy was first presented over 60 years ago with hematopoietic stem cell transplantation. However, complications such as graft versus host disease (GVHD) and regimen-related toxicities remained as major obstacles. To maximize the effect of graft versus leukemia, while minimizing the effect of GVHD, donor lymphocyte infusion was utilized. This idea, which was used against viral infections, postulated that adoptive transfer of virus-specific cytotoxic T lymphocytes could reconstitute specific immunity and eliminate virus infected cells and led to the idea of banking third party cytotoxic T cells (CTLs). T cell exhaustion sometimes became a problem and difficulty arose in creating robust CTLs. However, the introduction of induced pluripotent stem cells (iPSCs) lessens such problems, and by using iPSC technology, unlimited numbers of allogeneic rejuvenated CTLs with robust and proliferative cytotoxic activity can be created. Despite this revolutionary concept, several concerns still exist, such as immunorejection by recipient cells and safety issues of gene editing. In this review, we describe approaches to a feasible "off-the-shelf" therapy that can be distributed rapidly worldwide. We also offer perspectives on the future of allogeneic cell cancer immunotherapy.
Palavras-chave
CART therapy; T cell exhaustion; allogeneic cell cancer immunotherapy; donor lymphocyte infusion; gene editing; graft versus host disease; graft versus leukemia; induced pluripotent stem cells; inducible caspase-9; rejuvenated CTL; virus-specific cytotoxic T lymphocytes; "off-the-shelf" T cell therapy
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
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Células-Tronco Pluripotentes Induzidas
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Terapia Baseada em Transplante de Células e Tecidos
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Edição de Genes
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article