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Deciphering Biomarkers for Leptomeningeal Metastasis in Malignant Hemopathies (Lymphoma/Leukemia) Patients by Comprehensive Multipronged Proteomics Characterization of Cerebrospinal Fluid.
Juanes-Velasco, Pablo; Galicia, Norma; Pin, Elisa; Jara-Acevedo, Ricardo; Carabias-Sánchez, Javier; García-Valiente, Rodrigo; Lecrevisse, Quentin; Pedreira, Carlos Eduardo; Gongora, Rafael; Sanchez-Santos, Jose Manuel; Lorenzo-Gil, Héctor; Landeira-Viñuela, Alicia; Bareke, Halin; Orfao, Alberto; Nilsson, Peter; Fuentes, Manuel.
Afiliação
  • Juanes-Velasco P; Deparment of Medicine and General Servive of Cytometry, Cancer Research Centre-IBMCC, CSIC-USAL, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Galicia N; Deparment of Medicine and General Servive of Cytometry, Cancer Research Centre-IBMCC, CSIC-USAL, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Pin E; Proteomics Unit, Cancer Research Centre-IBMCC, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Jara-Acevedo R; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, 11428 Stockholm, Sweden.
  • Carabias-Sánchez J; Immunostep S.L. Institute of Cancer Research, Av. Universidad de Coimbra, 37007 Salamanca, Spain.
  • García-Valiente R; Proteomics Unit, Cancer Research Centre-IBMCC, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Lecrevisse Q; Proteomics Unit, Cancer Research Centre-IBMCC, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Pedreira CE; Deparment of Medicine and General Servive of Cytometry, Cancer Research Centre-IBMCC, CSIC-USAL, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Gongora R; Systems and Computing Department (COPPE-PESC), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-914, Brazil.
  • Sanchez-Santos JM; Deparment of Medicine and General Servive of Cytometry, Cancer Research Centre-IBMCC, CSIC-USAL, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Lorenzo-Gil H; Statistics Department, University of Salamanca, 37008 Salamanca, Spain.
  • Landeira-Viñuela A; Deparment of Medicine and General Servive of Cytometry, Cancer Research Centre-IBMCC, CSIC-USAL, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Bareke H; Deparment of Medicine and General Servive of Cytometry, Cancer Research Centre-IBMCC, CSIC-USAL, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Orfao A; Deparment of Medicine and General Servive of Cytometry, Cancer Research Centre-IBMCC, CSIC-USAL, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Nilsson P; Deparment of Medicine and General Servive of Cytometry, Cancer Research Centre-IBMCC, CSIC-USAL, IBSAL, Campus Miguel de Unamuno s/n, University of Salamanca-CSIC, 37007 Salamanca, Spain.
  • Fuentes M; Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, 11428 Stockholm, Sweden.
Cancers (Basel) ; 14(2)2022 Jan 17.
Article em En | MEDLINE | ID: mdl-35053611
ABSTRACT
In the present work, leptomeningeal disease, a very destructive form of systemic cancer, was characterized from several proteomics points of view. This pathology involves the invasion of the leptomeninges by malignant tumor cells. The tumor spreads to the central nervous system through the cerebrospinal fluid (CSF) and has a very grim prognosis; the average life expectancy of patients who suffer it does not exceed 3 months. The early diagnosis of leptomeningeal disease is a challenge because, in most of the cases, it is an asymptomatic pathology. When the symptoms are clear, the disease is already in the very advanced stages and life expectancy is low. Consequently, there is a pressing need to determine useful CSF proteins to help in the diagnosis and/or prognosis of this disease. For this purpose, a systematic and exhaustive proteomics characterization of CSF by multipronged proteomics approaches was performed to determine different protein profiles as potential biomarkers. Proteins such as PTPRC, SERPINC1, sCD44, sCD14, ANPEP, SPP1, FCGR1A, C9, sCD19, and sCD34, among others, and their functional analysis, reveals that most of them are linked to the pathology and are not detected on normal CSF. Finally, a panel of biomarkers was verified by a prediction model for leptomeningeal disease, showing new insights into the research for potential biomarkers that are easy to translate into the clinic for the diagnosis of this devastating disease.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Screening_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Screening_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article