Solvent-Free Synthesis, In Vitro and In Silico Studies of Novel Potential 1,3,4-Thiadiazole-Based Molecules against Microbial Pathogens.

Shehadi, Ihsan A; Abdelrahman, Mohamad T; Abdelraof, Mohamed; Rashdan, Huda R M

Shehadi, Ihsan A; Abdelrahman, Mohamad T; Abdelraof, Mohamed; Rashdan, Huda R M.

Afiliação

Shehadi IA; Pure and Applied Chemistry Research Group, Department of Chemistry, College of Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Abdelrahman MT; Nuclear Research Centre, Radioisotopes Department, Egyptian Atomic Energy Authority, Cairo P.O. Box 12622, Egypt.
Abdelraof M; National Research Centre, Microbial Chemistry Department, Biotechnology Research Institute, 33 El Bohouth St. (Former El Tahrir St.), Giza P.O. Box 12622, Egypt.
Rashdan HRM; National Research Centre, Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, Dokki, Cairo P.O. Box 12622, Egypt.

Molecules ; 27(2)2022 Jan 06.

Article em En | MEDLINE | ID: mdl-35056655

Assuntos

Anti-Infecciosos/síntese química; Anti-Infecciosos/farmacologia; Bactérias/efeitos dos fármacos; Simulação por Computador; Fungos/efeitos dos fármacos; Solventes/química; Tiadiazóis/química

Palavras-chave

1,3,4-thiadiazoles; MIC; antimicrobial; grindstone chemistry; molecular docking; molecular dynamics simulations

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Solventes / Tiadiazóis / Bactérias / Simulação por Computador / Fungos / Anti-Infecciosos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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