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Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms.
Schugar, Rebecca C; Gliniak, Christy M; Osborn, Lucas J; Massey, William; Sangwan, Naseer; Horak, Anthony; Banerjee, Rakhee; Orabi, Danny; Helsley, Robert N; Brown, Amanda L; Burrows, Amy; Finney, Chelsea; Fung, Kevin K; Allen, Frederick M; Ferguson, Daniel; Gromovsky, Anthony D; Neumann, Chase; Cook, Kendall; McMillan, Amy; Buffa, Jennifer A; Anderson, James T; Mehrabian, Margarete; Goudarzi, Maryam; Willard, Belinda; Mak, Tytus D; Armstrong, Andrew R; Swanson, Garth; Keshavarzian, Ali; Garcia-Garcia, Jose Carlos; Wang, Zeneng; Lusis, Aldons J; Hazen, Stanley L; Brown, Jonathan Mark.
Afiliação
  • Schugar RC; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Gliniak CM; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Osborn LJ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Massey W; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Sangwan N; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Horak A; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Banerjee R; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Orabi D; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Helsley RN; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Brown AL; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Burrows A; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Finney C; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Fung KK; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Allen FM; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Ferguson D; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Gromovsky AD; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Neumann C; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Cook K; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • McMillan A; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Buffa JA; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Anderson JT; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Mehrabian M; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Goudarzi M; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Willard B; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Mak TD; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Armstrong AR; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Swanson G; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Keshavarzian A; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Garcia-Garcia JC; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Wang Z; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Lusis AJ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
  • Hazen SL; Center for Microbiome and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
  • Brown JM; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, United States.
Elife ; 112022 01 24.
Article em En | MEDLINE | ID: mdl-35072627

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colina / Ritmo Circadiano / Microbioma Gastrointestinal / Obesidade Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colina / Ritmo Circadiano / Microbioma Gastrointestinal / Obesidade Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article