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Glutamatergic receptor and neuroplasticity in depression: Implications for ketamine and rapastinel as the rapid-acting antidepressants.
Wang, Ya-Ting; Zhang, Ning-Ning; Liu, Ling-Jie; Jiang, Hong; Hu, Die; Wang, Zhen-Zhen; Chen, Nai-Hong; Zhang, Yi.
Afiliação
  • Wang YT; Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China.
  • Zhang NN; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • Liu LJ; Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China.
  • Jiang H; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • Hu D; Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China.
  • Wang ZZ; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • Chen NH; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: chennh@imm.ac.cn.
  • Zhang Y; Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China. Electronic address: yzhang@bucm.edu.cn.
Biochem Biophys Res Commun ; 594: 46-56, 2022 02 26.
Article em En | MEDLINE | ID: mdl-35074585
PURPOSE OF REVIEW: To explore the convergent downstream pathways of ketamine and rapastinel and drive further development of identification for following generational rapid-acting antidepressants in the synaptic process. RECENT FINDINGS: Ketamine is an NMDAR antagonist and is proven effective in depression for the rapid and sustained antidepressant response, while rapastinel is an NMDAR positive allosteric modulator, producing antidepressant effects like ketamine with no severe side effects. The common antidepressant effects of ketamine and rapastinel are BDNF and mTORC1 pathway in synaptic plasticity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Receptores de N-Metil-D-Aspartato / Receptores de Neurotransmissores / Depressão / Alvo Mecanístico do Complexo 1 de Rapamicina / Ketamina / Antidepressivos / Plasticidade Neuronal Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Receptores de N-Metil-D-Aspartato / Receptores de Neurotransmissores / Depressão / Alvo Mecanístico do Complexo 1 de Rapamicina / Ketamina / Antidepressivos / Plasticidade Neuronal Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article