MicroRNA miR-7 Is Essential for Post-stroke Functional Recovery.
Transl Stroke Res
; 14(1): 111-115, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-35088373
ABSTRACT
Transient focal ischemia induces a sustained downregulation of miR-7 leading to derepression of its target α-synuclein (α-Syn), which promotes neuronal death. We previously showed that treatment with miR-7 mimic prevents α-Syn induction and protects brain after stroke in rodents irrespective of age and sex. To further decipher the role of miR-7, we currently studied infarction and motor function in miR-7 double knockout mice (lack both miR-7a and miR-7b) subjected to focal ischemia. Adult miR-7-/- mice showed similar motor and cognitive functions to miR-7+/+ mice. However, when subjected to even a mild focal ischemia, the miR-7-/- mice showed exacerbated brain damage and worsened motor function compared with the miR-7+/+ mice. Replenishing miR-7 in miR-7-/- mice (IV injection of miR-7 mimic) restored miR-7 mediated neuroprotection and motor recovery, potentially by preventing α-Syn protein induction. Thus, we show that miR-7 is an essential miRNA in the brain that prevents α-Syn translation and the ensuing brain damage after stroke.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Isquemia Encefálica
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Acidente Vascular Cerebral
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MicroRNAs
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article