Focused Ultrasound-Mediated Intranasal Brain Drug Delivery Technique (FUSIN).
Methods Mol Biol
; 2394: 501-513, 2022.
Article
em En
| MEDLINE
| ID: mdl-35094343
ABSTRACT
The blood-brain barrier (BBB) is the major barrier for brain drug delivery and limits the treatment options for central nervous system diseases. To circumvent the BBB, we introduced the focused ultrasound-mediated intranasal brain drug delivery (FUSIN) technique. FUSIN utilizes the nasal route for direct nose-to-brain drug administration, bypassing the BBB and minimizing systemic exposure. It also uses the transcranial application of ultrasound energy focused at a targeted brain region to induce microbubble cavitation, which enhances the transport of intranasally administered agents at the FUS-targeted brain location. FUSIN is unique in that it can achieve noninvasive and localized brain drug delivery with minimized systemic toxicity. The goal of this chapter is to provide a detailed protocol for FUSIN delivery to the mouse brain.
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Tipo de estudo:
Guideline
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Animals
Idioma:
En
Ano de publicação:
2022
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Article