Chemodivergent Synthesis of Allylic Sulfones via Ligand-Controlled Coupling of Allenes with Sulfinic Acids.
Org Lett
; 24(5): 1195-1200, 2022 02 11.
Article
em En
| MEDLINE
| ID: mdl-35099193
ABSTRACT
Allylic sulfones are important building blocks in organic synthesis and pharmaceutical chemistry. Herein, we disclose a chemodivergent protocol for Pd-catalyzed and ligand-controlled coupling of allenes with sulfinic acids, providing straightforward and atom-economical access to branched allylic sulfones and linear allylic sulfones bearing a conjugated (Z,E)-1,3-diene scaffold in good yields with high selectivities. This strategy features mild conditions, an unprecedented substrate scope, and functional group compatibility.
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MEDLINE
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En
Ano de publicação:
2022
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Article