Activation of osteoblast ferroptosis via the METTL3/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss.

Lin, Youfen; Shen, Ximei; Ke, Yuzhen; Lan, Chao; Chen, Xiaoyuan; Liang, Bo; Zhang, Yongze; Yan, Sunjie

Lin, Youfen; Shen, Ximei; Ke, Yuzhen; Lan, Chao; Chen, Xiaoyuan; Liang, Bo; Zhang, Yongze; Yan, Sunjie.

Afiliação

Lin Y; Department of Endocrinology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Shen X; Department of Endocrinology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Ke Y; Clinical Research Center for Metabolic Diseases of Fujian Province, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Lan C; Diabetes Research Institute of Fujian Province, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Chen X; Metabolic Diseases Research Institute, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Liang B; Department of Endocrinology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Zhang Y; Department of Endocrinology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Yan S; Department of Endocrinology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

FASEB J ; 36(3): e22147, 2022 03.

Article em En | MEDLINE | ID: mdl-35104016

Assuntos

Diabetes Mellitus/metabolismo; Ferroptose/fisiologia; Glucose/metabolismo; MAP Quinase Quinase Quinase 5/metabolismo; Metiltransferases/metabolismo; Osteoblastos/metabolismo; Osteoporose/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo; Células 3T3; Animais; Diferenciação Celular/fisiologia; Linhagem Celular; Dieta Hiperlipídica/efeitos adversos; Feminino; Camundongos; Camundongos Endogâmicos BALB C; Osteogênese/fisiologia; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/fisiologia

Palavras-chave

diabetes mellitus; ferroptosis; glycolipid toxicity; m6A modifications; osteoporosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoblastos / Osteoporose / MAP Quinase Quinase Quinase 5 / Proteínas Quinases p38 Ativadas por Mitógeno / Diabetes Mellitus / Ferroptose / Glucose / Metiltransferases Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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