Sequelae following infantile haemangiomas treated with propranolol.
Eur J Dermatol
; 31(6): 785-790, 2021 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-35107070
ABSTRACT
BACKGROUND:
Oral propranolol accelerates the involution of infantile haemangiomas (IHs). However, it is not clear whether IHs treated with oral propranolol are associated with fewer sequelae than when left untreated.OBJECTIVES:
To quantify and describe sequelae associated with IHs treated with oral propranolol, and to explore whether treated IHs are associated with fewer sequelae than untreated IHs. MATERIALS &METHODS:
This multicentre, retrospective, cohort study included patients with IH treated with oral propranolol ≥2 mg/kg for at least six months, with photographic images available at baseline and at age 4-5 years. A historical comparison cohort comprised 185 patients with untreated IHs. Main outcomes/measures were IH features, treatment characteristics and type/degree of sequelae.RESULTS:
Oral propranolol, most commonly at 2 mg/kg/day (mean duration nine months), was initiated in 171 patients (mean age 6.02 months). After treatment, 125 of 171 (73.1%) IHs were associated with no/minimal sequelae. The most common sequelae were telangiectasia (78%), fibrofatty tissue (37%) and anetodermic skin (28%). Deep IHs were associated with significantly fewer sequelae than other subtypes. Ulceration appeared to increase the likelihood of severe sequelae. IHs with a stepped border was associated with more severe sequelae than those with a progressive border (44% versus 27%, p < 0.05). Treated IHs resolved without sequelae or were associated with a sequela that did not need correction in 27.7% more cases than untreated IHs (RR 1.61; p < 0.001).CONCLUSION:
Among IHs treated with oral propranolol, 73% resolved without, or were associated with minimal sequelae. Deep IHs were associated fewer sequelae than other subtypes. Oral propranolol decreased the likelihood of IH sequelae requiring correction.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Propranolol
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Neoplasias Cutâneas
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Hemangioma
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Antineoplásicos
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article