Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus.
Biochem Biophys Res Commun
; 596: 29-35, 2022 03 12.
Article
em En
| MEDLINE
| ID: mdl-35108651
ABSTRACT
Thymic dendritic cells (DCs) promote immune tolerance by regulating negative selection of autoreactive T cells in the thymus. How DC homing to the thymus is transcriptionally regulated is still unclear. Microphthalmia-associated transcription factor (Mitf) is broadly expressed and plays essential roles in the hematopoietic system. Here, we used Mitf-mutated mice (Mitfvit/vit) and found enlargement of the thymus and expansion of CD4/CD8 double-positive T cells. Mitf was highly expressed in a subset of thymic DCs among the hematopoietic system. Genetic mutation or pharmacological inhibition of Mitf in DCs decreased the expression levels of Itga4, which are critical molecules for the homing of DCs to the thymus. Further, inhibition of Mitf decreased thymic DC number. These results suggest a pivotal role of Mitf in the maintenance of T cell differentiation by regulating the homing of DC subsets within the thymus.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Timo
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Células Dendríticas
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Linfócitos T
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Diferenciação Celular
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Fator de Transcrição Associado à Microftalmia
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article