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Sex differences in cortical thickness and diffusion properties in patients with traumatic brain injury: a pilot study.
Adamson, Maheen M; Main, Keith; Harris, Odette A; Kang, Xiaojian.
Afiliação
  • Adamson MM; Rehabilitation Service, VA Palo Alto Health Care System, Palo Alto, California, USA.
  • Main K; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA.
  • Harris OA; Research Division, Traumatic Brain Injury Center of Excellence, Silver Spring, Maryland, USA.
  • Kang X; General Dynamics Information Technology, Falls Church, Virginia, USA.
Brain Inj ; 36(4): 488-502, 2022 03 21.
Article em En | MEDLINE | ID: mdl-35113752
OBJECTIVE: Cortical thickness and diffusion properties are important measures of gray and white matter integrity in those with traumatic brain injury (TBI). Many studies show that healthy adult females have greater cortical thickness than males across numerous brain sites. In this study, we explored this sex difference in patients with TBI. METHOD: Participants consisted of 32 patients with TBI and 21 neurologically healthy controls. All were scanned by magnetic resonance imaging (MRI). Differences in cortical thickness and diffusion properties were examined between groups (i.e., TBI/control, male/female). RESULTS: Patients with TBI had more cortical thinning (both hemispheres) compared to controls. They also showed decreased fractional anisotropy (FA) for several major white matter tracts. Healthy females had significantly greater cortical thickness compared to healthy males. However, this difference was smaller among the patients with TBI. We found no sex differences in diffusion properties. There were moderate correlations between cortical thickness, diffusion properties, and cognitive performance, as measured by the Trail Making Test B. CONCLUSION: These findings contribute to a growing discussion on sex differences in cortical thickness and diffusion properties. Sexual dimorphism could necessitate different clinical profiles, targets, and rehabilitation strategies in patients with TBI.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Substância Branca / Lesões Encefálicas Traumáticas Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Substância Branca / Lesões Encefálicas Traumáticas Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article