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Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment and Children's Study.
Suzuki, Taeko; Nishigori, Toshie; Obara, Taku; Masumoto, Toshio; Mori, Miyuki; Murata, Tsuyoshi; Kyozuka, Hyo; Ogata, Yuka; Sato, Akiko; Sampei, Mari; Takahashi, Toshifumi; Shinoki, Kosei; Hosoya, Mitsuaki; Fujimori, Keiya; Yasumura, Seiji; Hashimoto, Koichi; Goto, Aya; Nishigori, Hidekazu.
Afiliação
  • Suzuki T; Department of Development and Environmental Medicine, Fukushima Medical Center for Children and Women, Fukushima Medical University Graduate School of Medicine, 1 Hikarigaoka, Fukushima-city, Fukushima960-1295, Japan.
  • Nishigori T; Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
  • Obara T; Preparing section for School of Midwifery, Fukushima Medical University, Fukushima, Japan.
  • Masumoto T; Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
  • Mori M; Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
  • Murata T; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan.
  • Kyozuka H; Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Ogata Y; Department of Development and Environmental Medicine, Fukushima Medical Center for Children and Women, Fukushima Medical University Graduate School of Medicine, 1 Hikarigaoka, Fukushima-city, Fukushima960-1295, Japan.
  • Sato A; Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
  • Sampei M; Department of Midwifery and Maternal Nursing, Fukushima Medical University School of Nursing, Fukushima, Japan.
  • Takahashi T; Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
  • Shinoki K; Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan.
  • Hosoya M; Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
  • Fujimori K; Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan.
  • Yasumura S; Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
  • Hashimoto K; Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
  • Goto A; Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
  • Nishigori H; Preparing section for School of Midwifery, Fukushima Medical University, Fukushima, Japan.
Br J Nutr ; 128(12): 2480-2489, 2022 12 28.
Article em En | MEDLINE | ID: mdl-35115066
We evaluated the association between maternal prenatal folic acid supplementation/dietary folate intake and motor and cognitive development in 2-year-old offspring using data from the Japan Environment and Children's Study database. Neurodevelopment of 2-year-old offspring were evaluated using the Kyoto Scale of Psychological Development 2001. In total, data of 3839 offspring were analysed. For folic acid supplementation, a multiple regression analysis showed that offspring of mothers who started using folic acid supplements before conception had a significantly lower developmental quotient (DQ) in the postural-motor DQ area than offspring of mothers who did not use them at any time throughout their pregnancy (partial regression coefficient (B) -2·596, 95 % CI -4·738, -0·455). Regarding daily dietary folate intake from preconception to early pregnancy, a multiple regression analysis showed that the group with ≥ 200 µg had a significantly higher DQ in the language-social area than the group with <200 µg. The DQ was higher in the ≥ 400 µg group (B 2·532, 95 % CI 0·201, 4·863) than the 200 to <400 µg group (B 1·437, 95 % CI 0·215, 2·660). In conclusion, our study showed that maternal adequate dietary folate intake from preconception to early pregnancy has a beneficial association with verbal cognition development in 2-year-old offspring. On the other hand, mothers who started using folic acid supplements before conception had an inverse association with motor development in 2-year-old offspring. There were no details on the amount of folic acid in the supplements used and frequency of use. Therefore, further studies are required.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Suplementos Nutricionais / Ácido Fólico Limite: Child / Child, preschool / Female / Humans / Pregnancy País como assunto: Asia Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Suplementos Nutricionais / Ácido Fólico Limite: Child / Child, preschool / Female / Humans / Pregnancy País como assunto: Asia Idioma: En Ano de publicação: 2022 Tipo de documento: Article