An increasing trend of human sapovirus infection in Japan, 2009 to 2019: An emerging public health concern.
J Infect Public Health
; 15(3): 315-320, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-35124328
ABSTRACT
BACKGROUND:
Human sapovirus (SaV) is an important etiologic agent of childhood diarrhea. This study aims to investigate the burden of SaV infection in childhood diarrhea in Japan from 2009-2019, to understand the changes in SaV infection after the introduction of rotavirus (RV) vaccination in Japan in 2011.METHODS:
Stool samples were collected from children aged ≤ 12 years old with acute gastroenteritis (AGE) who visited outpatient clinics of six prefectures in Japan. The viral RNA was detected by RT-PCR and genogroups and genotypes were determined through sequence-based analysis.RESULTS:
Among 5697 stool samples, 318 (5.6%) samples remained SaV-positives showing the highest prevalence in June and 12-24 month aged children. The most predominant genotype was GI.1 (56.8%), followed by GI.2 (19.2%), GII.1 (10.8%), GIV.1 (9.4%), GI.3 (1.7%), GII.2 (1.4%), GII.3 and GII.5 (0.3%). Importantly, an increasing trend (P = 0.016) of SaV infection was observed during this period. In particular, SaV-detection rate was increased significantly (P = 0.033) from 4.3% in pre-rotavirus (RV)-vaccination era to 6.1% in post-RV-vaccination era. We provided evidence that this increase in SaV infection was mainly attributed by coinfections.CONCLUSIONS:
The upward trend of SaV infection, particularly after the introduction of RV-vaccination, is an emerging concern. Attention should be paid to control this upward trend of SaV infection to ensure maximum benefits of implementation of RV vaccines towards reducing overall childhood diarrhea worldwide.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Caliciviridae
/
Sapovirus
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Child
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Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article