Gut Microbiome and Bile Acid Metabolism Induced the Activation of CXCR5+ CD4+ T Follicular Helper Cells to Participate in Neuromyelitis Optica Spectrum Disorder Recurrence.

Cheng, Xi; Zhou, Luyao; Li, Zhibin; Shen, Shishi; Zhao, Yipeng; Liu, Chunxin; Zhong, Xiaonan; Chang, Yanyu; Kermode, Allan G; Qiu, Wei

Cheng, Xi; Zhou, Luyao; Li, Zhibin; Shen, Shishi; Zhao, Yipeng; Liu, Chunxin; Zhong, Xiaonan; Chang, Yanyu; Kermode, Allan G; Qiu, Wei.

Afiliação

Cheng X; Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhou L; Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Li Z; Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Shen S; Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhao Y; Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Liu C; Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhong X; Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Chang Y; Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Kermode AG; Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Qiu W; Centre for Neuromuscular and Neurological Disorders, Perron Institute, The University of Western Australia, Perth, WA, Australia.

Front Immunol ; 13: 827865, 2022.

Article em En | MEDLINE | ID: mdl-35126400

Assuntos

Ácidos e Sais Biliares/metabolismo; Quimiocina CXCL13/sangue; Microbioma Gastrointestinal/fisiologia; Neuromielite Óptica/imunologia; Células T Auxiliares Foliculares/imunologia; Adulto; Animais; Autoimunidade; Biomarcadores/sangue; Antígenos CD4/metabolismo; Fezes/microbiologia; Feminino; Humanos; Proteína Coestimuladora de Linfócitos T Induzíveis/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Pessoa de Meia-Idade; Neuromielite Óptica/sangue; Receptores CXCR5/metabolismo; Recidiva; Linfócitos T Auxiliares-Indutores/imunologia

Palavras-chave

CXCL13; T follicular helper cells; bile acid; gut microbiota; neuromyelitis optica spectrum disorder

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos e Sais Biliares / Neuromielite Óptica / Quimiocina CXCL13 / Microbioma Gastrointestinal / Células T Auxiliares Foliculares Limite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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