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Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Ku, Zhiqiang; Xie, Xuping; Lin, Jianqing; Gao, Peng; El Sahili, Abbas; Su, Hang; Liu, Yang; Ye, Xiaohua; Li, Xin; Fan, Xuejun; Goh, Boon Chong; Xiong, Wei; Boyd, Hannah; Muruato, Antonio E; Deng, Hui; Xia, Hongjie; Jing, Zou; Kalveram, Birte K; Menachery, Vineet D; Zhang, Ningyan; Lescar, Julien; Shi, Pei-Yong; An, Zhiqiang.
Afiliação
  • Ku Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Xie X; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, US
  • Lin J; NTU Institute of Structural Biology and School of Biological Sciences, Nanyang Technological University, 636921, Singapore.
  • Gao P; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • El Sahili A; NTU Institute of Structural Biology and School of Biological Sciences, Nanyang Technological University, 636921, Singapore.
  • Su H; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Liu Y; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, US
  • Ye X; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Li X; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Fan X; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Goh BC; NTU Institute of Structural Biology and School of Biological Sciences, Nanyang Technological University, 636921, Singapore.
  • Xiong W; Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, 138602, Singapore.
  • Boyd H; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Muruato AE; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Deng H; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, US
  • Xia H; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Jing Z; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, US
  • Kalveram BK; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, US
  • Menachery VD; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, US
  • Zhang N; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Lescar J; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Shi PY; NTU Institute of Structural Biology and School of Biological Sciences, Nanyang Technological University, 636921, Singapore.
  • An Z; Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, US
bioRxiv ; 2022 Feb 01.
Article em En | MEDLINE | ID: mdl-35132410
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article