An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase.
EMBO Rep
; 23(3): e52669, 2022 02 03.
Article
em En
| MEDLINE
| ID: mdl-35132760
ABSTRACT
The size of lipid droplets varies greatly in vivo and is determined by both intrinsic and extrinsic factors. From an RNAi screen in Drosophila, we found that knocking down subunits of COP9 signalosome (CSN) results in enlarged lipid droplets under high-fat, but not normal, conditions. We identified CG2064, a retinol dehydrogenase (RDH) homolog, as the proteasomal degradation target of CSN in regulating lipid droplet size. RDH/CG2064 interacts with the lipid droplet-resident protein Plin2 and the RDH/CG2064-Plin2 axis acts to reduce the overall level and lipid droplet localization of Bmm/ATGL lipase. This axis is important for larval survival under prolonged starvation. Thus, we discovered an RDH-Plin2 axis modulates lipid droplet size.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Drosophila
/
Gotículas Lipídicas
/
Perilipina-2
/
Lipase
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article