Opioid-Related Constipation.
Gastroenterol Clin North Am
; 51(1): 107-121, 2022 03.
Article
em En
| MEDLINE
| ID: mdl-35135657
ABSTRACT
Opioid-related constipation encompasses constipation directly caused by opioid use (opioid-induced constipation [OIC]) as well as pre-existing constipation worsened by opioid use (opioid-exacerbated constipation [OEC]). Over-the-counter laxatives should be used as first-line agents for both OIC and OEC, given their efficacy, low cost, and high safety profiles. Symptoms of OIC and responses to therapy can be assessed with the Bowel Function Index. Individuals with OIC refractory to laxatives may be responsive to peripherally acting µ-opioid receptor antagonists. Although data supporting the superiority of one prescription agent over another is lacking, all have proven effective for the treatment of OIC.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Constipação Intestinal
/
Analgésicos Opioides
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article